Symptoms: severe nausea, temporary hearing loss, vomiting, diarrhea. Treatment: to gastric lavage and other measures emergency, in order to reduce the absorption of azithromycin designate activated carbon, magnesium- or calcium-containing antacids, to ensure adequate intake buy testosterone enanthate of fluid with adequate diuresis.
Interaction with other drugs
Antacids do not affect the azithromycin bioavailability, but reduce the maximum concentration blood plasma so be azithromycin take at least 1 hour before or 2 hours after administration of these drugs or food.
Azithromycin no effect the concentration of carbamazepine, cimetidine, didanosine, efavirenz, fluconazole, indinavir, midazolam, theophylline, triazolam, trimethoprim / sulfamethoxazole, cetirizine, sildenafil, atorvastatin, rifabutin and methylprednisolone in the plasma, while the application.
while the use of indirect antikoauglyantami (warfarin, other anticoagulants of the coumarin type) azithromycin (in normal doses) changes in prothrombin time is not revealed, however, given that the interaction of macrolides and warfarin may increase the anticoagulant effect, patients requires careful monitoring of the prothrombin time.
if necessary, the simultaneous application of cyclosporine is recommended to monitor the concentration of cyclosporine in plasma blood should be adjusted in dose of cyclosporine.
With the simultaneous use of digoxin and azithromycin is necessary to control the concentration of digoxin in the blood plasma, because many macrolides enhance the absorption of digoxin in the intestine.
While the use of zidovudine azithromycin had little effect on the buy testosterone enanthate pharmacokinetics, including the removal of the kidneys, zidovudine or its glucuronide metabolite.
However, azithromycin increases the concentration of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. The clinical relevance of this observation is unclear, but it may be helpful to patients.
Simultaneous use of azithromycin) causes an increase in the concentration of azithromycin. Clinically significant adverse events were observed, dose adjustment is not required.
Azithromycin weakly interacts with the cytochrome , is not revealed that azithromycin is involved in pharmacokinetic interactions similar to erythromycin and other macrolides, azithromycin is not an inducer and an inhibitor of cytochrome. Ergotamine and dihydroergotamine: strengthening of the toxic effect (vasospasm, dysesthesia). Macrolides slow excretion, increase the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine and drugs undergoing microsomal oxidation (cyclosporine, geksobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine , phenytoin, hypoglycemic drugs for oral), however, the application azalides (azithromycin including) this type of interaction was observed. Lincosamides weaken and tetracycline andchloramphenicol enhance the efficacy of azithromycin. anecdotal reports of cases of rhabdomyolysis have been obtained buy testosterone enanthate in patients while taking azithromycin and statins. with the simultaneous use of azithromycin and rifabutin sometimes neutropenia was observed, despite the fact that neutropenia associated with the use of rifabutin, a causal relationship between the use of a combination of azithromycin and rifabutin and neutropenia has not been established.