Pregnancy Specific embriopaty in children whose mothers received ethosuximide as monotherapy, was not found. On the background of the use of antiepileptic drugs increase the risk of malformations, the risk is higher for combined therapy, so monotherapy enanthate testosterone is recommended during pregnancy. It is necessary to assign the minimum effective dose, controlling seizures, especially between 20 and 40 days of pregnancy. It is necessary to regularly determine the concentration of ethosuximide in maternal serum. In the last trimester of pregnancy, a woman should take , this prevents the development of the newborn deficiency of vitamin K, which can lead to bleeding. It is necessary to warn the patient about the need for immediate treatment to the doctor during pregnancy occurs in the background therapy. Lactation The treatment should abandon breastfeeding because concentration in breast milk can be up to 94% concentration in maternal blood plasma.
Dosage and administration of single and daily doses depends on the clinical picture of the disease, the individual patient’s response to treatment and tolerability. The treatment is initiated with smaller initial doses. The doses are gradually increased. And in children and in adults, treatment is initiated with a total daily dose of ethosuximide in the range from 5 to 10 mg / kg body weight. The overall daily dose ethosuximide may increase at 5 mg / kg at intervals of 4 to 7 days ( or, depending on the equilibrate 8-10 days). . For maintenance therapy is usually sufficient daily dose ethosuximide rate of 20 mg / kg in children and 15 mg / kg for adults should not exceed the maximum daily dose ethosuximide 40 mg / kg body weight in children and 30 mg / kg – in adults. The daily dose take 2-3 hours.Because of the long half-life of ethosuximide with good tolerability entire daily dose can be administered simultaneously. Therapeutic ethosuximide concentrations in serum is 40-100 ug / ml. Examples of calculation of the daily dose for adults and children over 12 years with a maintenance dose of ethosuximide 15 mg / kg.
- Therefore, patients on hemodialysis, or require an extra dose. changes in dosage regimen. 39-52% of the administered dose is removed during a 4-hour hemodialysis. Enanthate testosterone the capsules should be swallowed whole with sufficient liquid (eg a glass of water) during or after a meal. Basically antiepileptic therapy is carried out for a long time. The question of the correction, the duration and canceling therapy Suksilepom ® to decide a person with experience in the treatment of epilepsy. Typically, a dose reduction may then cancel the drug should not be taken as long as the period during which do not occur convulsions not be 2 or 3 of the year. Reducing the dose to abolish drug must be performed in several phases over a period of 1 to 2 years. For children permitted “grow” from its dose (dose remains constant, while the body weight increases). However, it should not be marked deterioration of parameters.Side effects Dose-dependent adverse effects are often observed nausea, vomiting, hiccups, and abdominal pain. Sometimes there are lethargy, withdrawal syndrome, severe headache, dizziness, anxiety, depression, sleep disturbances, decreased ability to concentrate, unusual fatigue, loss of appetite, weight loss, diarrhea or constipation, as in ataxia. In enanthate testosterone rare cases, several days or weeks may develop hallucinatory-paranoid ideation. In some cases, during the first 12 hours of treatment of dyskinesia observed. They disappear after canceling ethosuximide or controlled by diphenhydramine. Undesirable effects that do not depend on the dose can be observed allergic skin reactions such as rash; possible development of Stevens-Johnson syndrome. Rarely observed systemic lupus erythematosus, of varying intensity, leukopenia, eosinophilia, thrombocytopenia, or agranulocytosis. In isolated cases may develop aplastic anemia and pancytopenia.