testosterone cypionate vs enanthate

Testosterone cypionate vs enanthate – high, is acid, lipophilic. Bioavailability after a single dose of 0.5 g – 37% (the effect of “first pass” through the liver). The maximum plasma concentration (C max ) after oral administration is achieved in 2-3 hours and is 0.4 mg / l. Bioavailability is 37.5%. Distribution After oral administration, azithromycin is rapidly distributed throughout the body. The pharmacokinetic studies have higher levels of concentration of azithromycin in tissues than in plasma and serum. Communication plasma protein varies depending on the serum concentration: 52% at 0.05 mg / l and 12% with 0.5 mg / l.

The volume of distribution at steady state is 31.1 l / kg. It is easy to pass gistogematicalkie barriers.It penetrates into the respiratory tract, genitourinary organs and tissue, the prostate, the skin and soft tissues; It accumulates in low pH medium in the lysosomes (especially important in the eradication of intracellular pathogens located). Dispatching also phagocytes testosterone enanthate uk, polymorphonuclear leukocytes and macrophages. It penetrates through the cell membrane and creates a high concentration of them.

The concentration in the foci of infection was significantly higher (24-34%) than in healthy tissues, and is correlated with the severity of the inflammatory edema. The focus of inflammation is maintained at effective concentrations within 5-7 days after the last dose. . Communication with plasma proteins – 7-50% (inversely proportional to the concentration in the blood) Excretion Excretion of testosterone cypionate vs enanthate azithromycin from plasma takes place in two stages: in the range of 8 to 24 hours after . dosing and 41 hours – in the range of 24 to 72 hours, allowing you to use the drug 1 time per daywithdrawal of the drug mainly in the bile unchanged, a small portion excreted by the kidneys. Pharmacokinetics in special cases, patients with renal failure: after the introduction of one-off 1 g dose of azithromycin in patients with renal insufficiency of mild to moderate severity,  and area under the curve “concentration-time» AUC0-120 increased by 5.1% 4.2%, respectively, compared with the group of patients with normal renal function (GFR -> 80 ml / min).

In patients with severe renal insufficiency averages the testosterone cypionate vs enanthate increased by 61% and 33%, respectively. At end-stage renal failure (creatinine clearance less than 10 ml / min), there is an increase in plasma concentrations of azithromycin at 33%. Patients with hepatic impairment: patients with hepatic mild or moderate insufficiency not proved the existence of significant changes in the pharmacokinetics of azithromycin in serum as compared with patients with normal liver function.elderly patients: pharmacokinetics of azithromycin in elderly male patients was similar to the pharmacokinetics observed in patients young adults. In elderly patients, a significant female cumulation of azithromycin has not arisen.


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