testosterone enanthate dosage

After oral ethosuximide almost completely testosterone enanthate dosage absorbed. In adults, ethosuximide after administration in a single dose of 1 g of maximal concentration in plasma was determined after 2-4 hours and was 18-24 pg / ml . in children between the ages of 7 to 8.5 years with a body weight 12,9-24,4 kg ethosuximide after receiving a single dose of 500 mg the maximum plasma concentration is reached after. 3-7 hours and was 28-50,9 g / ml. In the dose and the increase in the plasma concentration, a linear relationship;with increasing oral doses of 1 mg / kg / day is supposed to increase in the plasma concentration of 2-3 mg / ml in children – 1-2 mg / ml. Therefore, young children require somewhat higher doses than older children.

Therapeutic ethosuximide plasma concentrations are in the range from 40 to 100 micrograms / ml. At concentrations in plasma over 150 mg / ml may develop toxic effects. Distribution in children after prolonged use of the drug at a dose of 20 mg / kg, plasma concentrations increased to nearly 50 micrograms / ml. In adults, this concentration is achieved while taking the drug at a dose of 15 mg / kg. The testosterone enanthate dosage equilibrium is expected to occur within 8-10 days after the start of therapy. There is considerable interindividual differences in plasma concentrations of the drug when used in the same doses as oral dosage forms. ethosuximide slightly bound to plasma proteins. Ethosuximide detected in the cerebrospinal fluid and saliva in the same concentration as in plasma. The apparent volume of distribution is 0.7 l / kg.

Penetrates through the placental barrier, excreted in breast milk (the ratio of the concentrations of ethosuximide in plasma and in breast milk is 0,94 ± 0,06). The metabolism, excretion in adults after taking ethosuximide orally in 13,1-18 single dose mg / kg of plasma half-life was 38,3-66,6 hours. in children after ingestion ethosuximide in a single dose of 500 mg of the plasma half-life was 25,7-35,9 h.ethosuximide expressed undergoes oxidative metabolism in the liver. formed several apparently pharmacologically inactive metabolites that are excreted by the kidneys and partly in the form of conjugates with glucuronic acid. The major metabolites are formed two diastereomers: 2- (1-hydroxyethyl) -2-methyl-succinimide and 2-ethyl-2-methyl-3-hydroxysuccinimide. The unchanged kidneys displayed 10-20%.

Indications

 

  • Attacks piknolepticheskih absences, as well as complex and atypical seizures.
    Note. In order to avoid the development of generalized tonic-clonic seizures, which are often exacerbated during the complex and atypical seizures, ethosuximide is possible to use a combination with anticonvulsants (eg, primidone, phenobarbital). For testosterone enanthate dosage more prevention generalized tonic-clonic seizures may be carried out without exception in the case of attacks piknolepticheskih absences in school-age children.
  • Myoclonic-astatic small seizures (petit mal).
  • Juvenile myoclonic seizures (fits small impulsive).Contraindications
    : Hypersensitivity to the drug.
    Do not use in children under 6 years due to the impossibility of accurate dosing of the dosage form.

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