Patients predisposed to the development of myopathy The recommended initial testosterone enanthate for patients with a predisposition to the development of myopathy is 5 mg. Use of the drug in such patients a dose of 40 mg is contraindicated (see. Section “Contraindications”). there was an increase of exposure of rosuvastatin and 1.6 2.4-fold, respectively, compared with native genotypes .
For carriers genotypes the recommended maximum is 20 mg once daily (see. section “Pharmacokinetics “). Concomitant therapy Rosuvastatin associated with various transport proteins . With the simultaneous with drugs (such as cyclosporine, some protease inhibitors of human immunodeficiency virus , including a combination of ritonavir with atazanavir, lopinavir and / or tipranavir), increases the concentration of rosuvastatin plasma due to interaction with transport proteins, may increase the risk of myopathy . In such cases it is necessary to evaluate the possibility of using an alternative therapy or temporary discontinuation . If necessary, the application of the above drugs should weigh the benefits and risks of concomitant therapy with Suvardio ® and consider lowering the dose.
Violations by the immune system rare: hypersensitivity reactions, including angioedema. Violations of the endocrine system frequent: diabetes 2- . type Disorders of the central nervous system common: headache, dizziness; very rare: polyneuropathy, memory loss. Violations of the respiratory frequency is not known: cough, shortness of breath.Disorders of the digestive system common: constipation, nausea, pain in belly, rarely: pancreatitis; frequency not known: diarrhea. Violations testosterone enanthate half life of the skin uncommon: pruritus, rash, urticaria, frequency is not known: Stevens-Johnson syndrome. Laboratory findings Increased activity of creatine phosphokinase (CPK), glucose, glycosylated hemoglobin, bilirubin plasma, the activity of gamma-glutamyl, alkaline phosphatase, dysfunction of the thyroid gland. Other common: asthenic syndrome, gynecomastia, peripheral edema. Violations of the urinary system is very rarely . hematuria , proteinuria may occur when taking rosuvastatin. Changes in protein content in urine (from absence to presence of trace amounts of up to and above the level ++) occur in less than 1% of patients taking rosuvastatin, 10 mg and 20 mg, and about 3%, taking the drug at a dose of 40 mg . Slight change in the amount of protein in urine, expressed as changes from zero or trace to a level of availability + observed while taking the drug at a dose of 20 mg. In most cases, proteinuria was reduced and held their own in the course of treatment. In the analysis of data from clinical studies have identified a causal relationship between proteinuria and acute or progressive renal disease. Violations of the musculoskeletal system and connective tissue disorders common: myalgia; rare: myopathy (including myositis), rhabdomyolysis; very rare: arthralgia; the frequency is unknown: . immune-mediated necrotizing myopathy Violations of the liver and biliary tract rare: increased activity of “liver” transaminases, very rare: jaundice, hepatitis. with some statins reported such side effects like depression, sleep disorders, including insomnia and nightmares, sexual dysfunction.
No specific treatment of overdosage with rosuvastatin does not exist.
In case of overdose symptomatic treatment is recommended and measures aimed at maintaining the function of vital organs and systems. It requires monitoring of liver function and CPK. It is unlikely that dialysis would be effective.
Interaction with other drugs
With simultaneous use of rosuvastatin and cyclosporine of rosuvastatin was on average 7 times higher than the value that was observed in healthy volunteers. The combined use of these drugs leads to increased plasma rosuvastatin concentrations in 11 times, and the plasma concentration of cyclosporine does not change (see. “Contraindications”).
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When using other statins had received reports of cases of rhabdomyolysis with the concomitant use of rosuvastatin and fusidic acid, necessary to monitor the condition of patients, if necessary possibly temporary discontinuation of rosuvastatin is used.
As in the case of other testosterone enanthate half life reductase, the beginning of therapy with rosuvastatin or increasing doses in patients receiving both vitamin K antagonists (e.g. warfarin or other coumarin anticoagulants) It can lead to an increase in the international normalized ratio . Cancellation or reduction of the dose of rosuvastatin can cause a decrease . In such cases it is necessary to monitor .
The simultaneous use of rosuvastatin and gemfibrozil and other means of reducing the concentration of lipid increases rosuvastatin 2 times. online anabolic steroids pharmacy
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