Antibacterial component of sulbactam testosterone enanthate injection third generation, which acts on the sensitive microorganisms during their active multiplication by inhibiting biosynthesis of cell wall peptidoglycan. Sulbactam has no clinically significant antibacterial activity. However, it was noted that it is the most major irreversible inhibitor of beta-lactamases, which are produced by microorganisms that are resistant to beta-lactam antibiotics.
The ability of sulbactam to prevent the destruction of penicillins and cephalosporins resistant microorganisms has been confirmed in studies using resistant strains, in respect of which sulbactam had pronounced synergism with penicillins and cephalosporins. Furthermore, sulbactam reacted with some penicillin-binding proteins, so sulbactam / cefoperazone often has a stronger effect on strains sensitive than one ceftazidime.
The combination of sulbactam and cefoperazone is active against all organisms sensitive to cefoperazone. In addition, it has a synergy against various microorganisms, particularly: Haemophilus influenzae, Bacteroides species, Staphylococcus species, Acinetobacter calcoaceticus, Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Enterobacter cloacae, Citrobacter diversus. sulbactam / cefoperazone is active in vitro against a broad range of clinically relevant microorganisms.
- Gram-positive organisms Staphylococcus aureus (producing and not producing penicillinase), Staphylococcus epidermidis, Streptococcus pneumoniae,Streptococcus pyogenes (beta-hemolytic streptococcus Group (betaA), hemolytic Streptococcus group B), most of other strains of beta-hemolytic streptococci, many strains of faecalis of Streptococcus (enterococcus).
- Gram-negative bacteria Escherichia coli, Klebsiella species, Enterobacter species, Citrobacter species, Haemophilus influenzae, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia species, Serratia species (including Serratia marcescens), Salmonella and Shigella species, Pseudomonas aeruginosa and some otherPseudomonas species, Acinetobacter calcoaceticus, Neisseria gonorrhoeae , Neisseria meningitidis, Bordetella pertussis, Yersinia enterocolitica.
- Anaerobic microorganisms Gramotrschatelnye sticks (including Bacteroides fragilis, other Bacteroides species and Fusobacterium species). Gram-positive and Gram-negative cocci (includingPeptococcus spp., Peptostreptococcus spp. And Veillonella species). Gram-positive daddy (including Clostridium spp., Eubacterium spp., And Lactobacillus species) .
The following sensitivity levels have been established for sulbactam / cefoperazone. The minimum inhibitory concentration testosterone enanthate injection in mcg / ml, expressed as cefoperazone concentration for sensitive microorganisms less than or equal to 16, for organisms with intermediate sensitivity is in the range 17-63, and for resistant – more than 64 sensitive areas in determining the disk diffusion method up : for sensitive microorganisms than 21 mm; intermediate sensitivity – 16 to 20 mm, and resistant to – more than 15 mm.
To determine the MIC can be used limiting dilution method sulbactam / cefoperazone in the ratio 1: 1 agar or broth media. To determine the IPC disk diffusion method is testosterone enanthate injection recommended to use a disc containing 30 mcg of sulbactam and 75 mcg of cefoperazone. The following quality control standards are recommended when using a disc containing 30 mcg of sulbactam and 75 mcg of cefoperazone. For the control strain .. legal steroids