The maximum concentration of sulbactam testosterone enanthate side effects cefoperazone and after intravenous administration of 2 g of sulbactam / cefoperazone (1 g sulbactam, cefoperazone 1 g) for 5 min averaged 130.2 and 236.8 ug / ml, respectively. This reflects the higher volume of distribution of sulbactam (Vd = 18,0-27,6 l) as compared with that cefoperazone (Vd = 10,2-11,3 L).
Following intramuscular administration of 1.5 grams of sulbactam / cefoperazone (0.5 g sulbactam, cefoperazone 1 g) and the maximum concentration of sulbactam cefoperazone serum observed in a period of 15 minutes to 2 hours after administration. The maximum serum concentrations were 19.0 and 64.2 mcg / ml sulbactam and cefoperazone, respectively.
As sulbactam and cefoperazone is well distributed in various tissues and body fluids, including bile, gall bladder, skin, appendix, fallopian tubes, ovaries, uterus, and others.
Approximately 84% of the dose, and 25% sulbactam testosterone enanthate side effects cefoperazone dose, administered as a combination – sulbactam / cefoperazone, kidneys displayed. Most of the remaining dose of cefoperazone is excreted in the bile. Cefoperazone does not displace bilirubin from binding with plasma proteins. The half-life of sulbactam is an average of about 1 hour, cefoperazone – 1.7 h Serum is proportional to the administered dose.. Data on the presence of a pharmacokinetic interaction between sulbactam and cefoperazone when administered sulbactam / cefoperazone not.
Repeated use of significant changes in the pharmacokinetics were observed both sulbactam / cefoperazone components. With the introduction of the drug every 8-12 hours accumulation was observed.
Application for violations of liver function
Since ceftazidime is actively excreted in the bile, the elimination half-life of cefoperazone is usually elongated and kidney excretion of the drug increased in patients with liver disease and / or obstruction of the biliary tract. Even with severe hepatic impairment in bile achieved therapeutic concentrations of cefoperazone, and elimination half-life only increased by 2-4 times.
Application for violations of renal function
in patients with varying degrees of renal impairment treated with sulbactam / cefoperazone, revealed a high correlation between the total clearance of sulbactam from the body and calculated creatinine clearance. In patients with end-stage renal failure showed a significant extension of the half-life of sulbactam (mean 6.9 and 9.7 hours in various studies). Hemodialysis causes a significant change in half-life, total clearance and volume of distribution of sulbactam.
Application of the elderly
pharmacokinetics of sulbactam / cefoperazone has been studied in elderly people with kidney failure, and impaired liver function. Compared with healthy volunteers showed an increase in the duration of half-life, decreased clearance and volume of distribution both increase sulbactam and cefoperazone. The pharmacokinetics of sulbactam correlated with the degree of renal dysfunction testosterone enanthate side effects and the pharmacokinetics of cefoperazone – with the degree of liver dysfunction.
Use in children
The studies in children showed no significant changes in the pharmacokinetics of the components of sulbactam / cefoperazone compared to those in adults. The average half-life of sulbactam in children ranged from 0.91 to 1.42 hours, cefoperazone – from 1.44 to 1.88 hours.
Sulperazon is indicated for the treatment of the following infections caused by susceptible microorganisms:
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infections of the upper and lower respiratory tract.
Infections of the upper and lower urinary tract.
Peritonitis, cholecystitis, cholangitis and other intra-abdominal infections.
Infections of the skin and soft tissues. Infections testosterone enanthate side effects of bones and joints.
Inflammatory diseases of the pelvic organs, endometritis, gonorrhea and other infections of the urogenital tract. anabolic steroids online shop
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